3g7t

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Template:STRUCTURE 3g7t

Contents

Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation

Template:ABSTRACT PUBMED 19244332

Function

[Q5USP2_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]

About this Structure

3g7t is a 1 chain structure with sequence from Dengue virus 1. Full crystallographic information is available from OCA.

Reference

  • Nayak V, Dessau M, Kucera K, Anthony K, Ledizet M, Modis Y. Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion. J Virol. 2009 May;83(9):4338-44. Epub 2009 Feb 25. PMID:19244332 doi:10.1128/JVI.02574-08

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