Publication Abstract from PubMed
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.
Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.,Abdo M, Liu S, Zhou B, Walls CD, Wu L, Knapp S, Zhang ZY J Am Chem Soc. 2008 Oct 8;130(40):13196-7. Epub 2008 Sep 10. PMID:18781746[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
