4hqb

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4hqb

Contents 1 Crystal structure of DdrB from Deinococcus radiodurans bound to ssDNA 2 Function 3 About this Structure 4 Reference

Crystal structure of DdrB from Deinococcus radiodurans bound to ssDNA

Template:ABSTRACT PUBMED 23975200

Function

[DDRB_DEIRA] ssDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Appears to play a role in DNA repair and genome reconstitution, in a RecA-independent process, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. Binds single-stranded DNA but not duplex DNA.^{[1] [2]}

About this Structure

4hqb is a 7 chain structure with sequence from "micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960. Full crystallographic information is available from OCA.

Reference

• Sugiman-Marangos SN, Peel JK, Weiss YM, Ghirlando R, Junop MS. Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states. Nucleic Acids Res. 2013 Aug 23. PMID:23975200 doi:10.1093/nar/gkt759

1. ↑ Tanaka M, Earl AM, Howell HA, Park MJ, Eisen JA, Peterson SN, Battista JR. Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistance. Genetics. 2004 Sep;168(1):21-33. PMID:15454524 doi:http://dx.doi.org/10.1534/genetics.104.029249
2. ↑ Norais CA, Chitteni-Pattu S, Wood EA, Inman RB, Cox MM. DdrB protein, an alternative Deinococcus radiodurans SSB induced by ionizing radiation. J Biol Chem. 2009 Aug 7;284(32):21402-11. doi: 10.1074/jbc.M109.010454. Epub 2009, Jun 10. PMID:19515845 doi:http://dx.doi.org/10.1074/jbc.M109.010454