4hsb

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Template:STRUCTURE 4hsb

Contents

S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA

Template:ABSTRACT PUBMED 23273506

Function

[MAG2_SCHPO] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.[1]

About this Structure

4hsb is a 3 chain structure with sequence from Fission yeast. Full crystallographic information is available from OCA.

Reference

  • Adhikary S, Cato MC, McGary KL, Rokas A, Eichman BF. Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe. DNA Repair (Amst). 2012 Dec 27. pii: S1568-7864(12)00290-X. doi:, 10.1016/j.dnarep.2012.12.001. PMID:23273506 doi:http://dx.doi.org/10.1016/j.dnarep.2012.12.001
  1. ↑ Kanamitsu K, Tanihigashi H, Tanita Y, Inatani S, Ikeda S. Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe. Genes Genet Syst. 2007 Dec;82(6):489-94. PMID:18270439

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