4klx

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Template:STRUCTURE 4klx

Contents

Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation.

Template:ABSTRACT PUBMED 24210757

Function

[DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4klx is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Dias MV, Tyrakis P, Domingues RR, Leme AF, Blundell TL. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure. 2013 Nov 6. pii: S0969-2126(13)00395-X. doi:, 10.1016/j.str.2013.09.022. PMID:24210757 doi:http://dx.doi.org/10.1016/j.str.2013.09.022

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