4afn

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Template:STRUCTURE 4afn

Contents

Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa at 2.3A resolution

Template:ABSTRACT PUBMED 24015914

Function

[FABG_PSEAE] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).

About this Structure

4afn is a 4 chain structure with sequence from Pseae. Full crystallographic information is available from OCA.

Reference

  • Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G. Discovery of an allosteric inhibitor binding site in 3-oxo-acyl-ACP reductase from Pseudomonas aeruginosa. ACS Chem Biol. 2013 Sep 9. PMID:24015914 doi:10.1021/cb4005063

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