4e2i

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Template:STRUCTURE 4e2i

Contents

The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase Alpha-Primase

Template:ABSTRACT PUBMED 22700977

Function

[DPOA2_HUMAN] May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity).

About this Structure

4e2i is a 23 chain structure with sequence from Homo sapiens and Simian virus 40. Full crystallographic information is available from OCA.

See Also

Reference

  • Zhou B, Arnett DR, Yu X, Brewster A, Sowd GA, Xie CL, Vila S, Gai D, Fanning E, Chen XS. Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase alpha-primase. J Biol Chem. 2012 Aug 3;287(32):26854-66. doi: 10.1074/jbc.M112.363655. Epub 2012, Jun 14. PMID:22700977 doi:10.1074/jbc.M112.363655

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