4ief

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Template:STRUCTURE 4ief

Contents

Complex of Porphyromonas gingivalis RgpB pro- and mature domains

Template:ABSTRACT PUBMED 23558682

Function

[CPG2_PORGI] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Its proteolytic activity is a major factor in both periodontal tissue destruction and in bacterial host defense mechanisms. Activates complement C3 and C5 (By similarity).

About this Structure

4ief is a 8 chain structure with sequence from Porphyromonas gingivalis w83. Full crystallographic information is available from OCA.

Reference

  • de Diego I, Veillard FT, Guevara T, Potempa B, Sztukowska M, Potempa J, Gomis-Ruth FX. Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases. J Biol Chem. 2013 May 17;288(20):14287-96. doi: 10.1074/jbc.M112.444927. Epub, 2013 Apr 4. PMID:23558682 doi:10.1074/jbc.M112.444927

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