Publication Abstract from PubMed
A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.,Lee J, Choi H, Kim KH, Jeong S, Park JW, Baek CS, Lee SH Bioorg Med Chem Lett. 2008 Apr 1;18(7):2292-5. Epub 2008 Mar 6. PMID:18353638[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
