4gc9
From Proteopedia
Contents |
Crystal structure of murine TFB1M in complex with SAM
Template:ABSTRACT PUBMED 23804760
Function
[TFB1M_MOUSE] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
About this Structure
4gc9 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Guja KE, Venkataraman K, Yakubovskaya E, Shi H, Mejia E, Hambardjieva E, Karzai AW, Garcia-Diaz M. Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1. Nucleic Acids Res. 2013 Jun 26. PMID:23804760 doi:10.1093/nar/gkt547
