Structural highlights
Publication Abstract from PubMed
STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.
The structural basis for the sensing and binding of cyclic di-GMP by STING.,Huang YH, Liu XY, Du XX, Jiang ZF, Su XD Nat Struct Mol Biol. 2012 Jun 24;19(7):728-30. doi: 10.1038/nsmb.2333. PMID:22728659[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Huang YH, Liu XY, Du XX, Jiang ZF, Su XD. The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol. 2012 Jun 24;19(7):728-30. doi: 10.1038/nsmb.2333. PMID:22728659 doi:http://dx.doi.org/10.1038/nsmb.2333
