4j24

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Template:STRUCTURE 4j24

Contents 1 Estrogen Receptor in complex with proline-flanked LXXLL peptides 2 Function 3 About this Structure 4 Reference

Estrogen Receptor in complex with proline-flanked LXXLL peptides

Template:ABSTRACT PUBMED 23437920

Function

[ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

About this Structure

4j24 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Fuchs S, Nguyen HD, Phan TT, Burton MF, Nieto L, de Vries-van Leeuwen IJ, Schmidt A, Goodarzifard M, Agten SM, Rose R, Ottmann C, Milroy LG, Brunsveld L. Proline Primed Helix Length as a Modulator of the Nuclear Receptor-Coactivator Interaction. J Am Chem Soc. 2013 Mar 7. PMID:23437920 doi:10.1021/ja311748r