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3o2f
From Proteopedia
Contents |
Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
Template:ABSTRACT PUBMED 23995768
Function
[ENPL_CANFA] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
About this Structure
3o2f is a 2 chain structure with sequence from Canfa. Full crystallographic information is available from OCA.
See Also
Reference
- Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. PMID:23995768 doi:10.1038/nchembio.1335
