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1m6d
From Proteopedia
Revision as of 04:30, 3 October 2014 by OCA (Talk | contribs)
1m6d is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with the major histocompatibility complex (MHC) class II. Evidence suggests that inhibiting cathepsin F activity will block MHC class II processing in macrophages. Consequently, inhibitors of this enzyme may be useful in treating certain diseases that involve an inappropriate or excessive immune response. We have determined the 1.7A structure of the mature domain of human cathepsin F associated with an irreversible vinyl sulfone inhibitor. This structure provides a basis for understanding cathepsin F's substrate specificity, and suggests ways of identifying potent and selective inhibitors of this enzyme.
The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.,Somoza JR, Palmer JT, Ho JD J Mol Biol. 2002 Sep 20;322(3):559-68. PMID:12225749[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Somoza JR, Palmer JT, Ho JD. The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators. J Mol Biol. 2002 Sep 20;322(3):559-68. PMID:12225749
