4itc

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Template:STRUCTURE 4itc

Contents

Crystal Structure Analysis of the K1 Cleaved Adhesin domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis W83

Template:ABSTRACT PUBMED 24265933

Function

[KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]

About this Structure

4itc is a 1 chain structure with sequence from Atcc 33277. Full crystallographic information is available from OCA.

Reference

  • Ganuelas LA, Li N, Yun P, Hunter N, Collyer CA. The lysine gingipain adhesin domains from Porphyromonas gingivalis interact with erythrocytes and albumin: Structures correlate to function. Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):152-62. doi:, 10.1556/EuJMI.3.2013.3.2. Epub 2013 Sep 23. PMID:24265933 doi:http://dx.doi.org/10.1556/EuJMI.3.2013.3.2

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