4o7d

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Template:STRUCTURE 4o7d

Contents

Crystal structure of human glutaminase in complex DON

Template:ABSTRACT PUBMED 24451979

Function

[GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

About this Structure

4o7d is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Thangavelu K, Chong QY, Low BC, Sivaraman J. Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827. PMID:24451979 doi:http://dx.doi.org/10.1038/srep03827

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OCA

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