4jal

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Template:STRUCTURE 4jal

Contents

Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH

Template:ABSTRACT PUBMED 23804755

Function

[TRML_ECOLI] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. Recognition of the target requires a pyridine at position 34 and N(6)-(isopentenyl)-2-methylthioadenosine at position 37.[1]

About this Structure

4jal is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

  • Liu RJ, Zhou M, Fang ZP, Wang M, Zhou XL, Wang ED. The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL. Nucleic Acids Res. 2013 Jun 26. PMID:23804755 doi:10.1093/nar/gkt568
  1. ↑ Benitez-Paez A, Villarroya M, Douthwaite S, Gabaldon T, Armengod ME. YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. RNA. 2010 Nov;16(11):2131-43. doi: 10.1261/rna.2245910. Epub 2010 Sep 20. PMID:20855540 doi:10.1261/rna.2245910

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