4nv0

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Template:STRUCTURE 4nv0

Contents

Crystal structure of cytosolic 5'-nucleotidase IIIB (cN-IIIB) bound to 7-methylguanosine

Template:ABSTRACT PUBMED 24603684

Function

[5NT3B_DROME] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.

About this Structure

4nv0 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Monecke T, Buschmann J, Neumann P, Wahle E, Ficner R. Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP. PLoS One. 2014 Mar 6;9(3):e90915. doi: 10.1371/journal.pone.0090915. eCollection , 2014. PMID:24603684 doi:http://dx.doi.org/10.1371/journal.pone.0090915

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