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2bat
From Proteopedia
Revision as of 01:15, 30 September 2014 by OCA (Talk | contribs)
2bat is a 1 chain structure with sequence from Viruses. The May 2009 RCSB PDB Molecule of the Month feature on Influenza Neuraminidase by David Goodsell is 10.2210/rcsb_pdb/mom_2009_5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.,Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM Proteins. 1992 Nov;14(3):327-32. PMID:1438172[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
