4nc3

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4nc3

Contents 1 Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase. 2 Function 3 About this Structure 4 Reference

Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.

Template:ABSTRACT PUBMED 24357322

Function

[5HT2B_HUMAN] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.

About this Structure

4nc3 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V. Serial femtosecond crystallography of G protein-coupled receptors. Science. 2013 Dec 20;342(6165):1521-4. doi: 10.1126/science.1244142. PMID:24357322 doi:http://dx.doi.org/10.1126/science.1244142