Structural highlights
Publication Abstract from PubMed
A series of nevirapine-based analogues containing the phosphonate functionality were prepared and evaluated in vitro against HIV RT. The effect of the phosphonate was evaluated against the wild type and Y181C HIV replication. An in vivo PK study was performed on a select analogue.
Synthesis and biological evaluation of phosphonate analogues of nevirapine.,Parrish J, Tong L, Wang M, Chen X, Lansdon EB, Cannizzaro C, Zheng X, Desai MC, Xu L Bioorg Med Chem Lett. 2013 Mar 1;23(5):1493-7. doi: 10.1016/j.bmcl.2012.12.049., Epub 2012 Dec 21. PMID:23375792[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Parrish J, Tong L, Wang M, Chen X, Lansdon EB, Cannizzaro C, Zheng X, Desai MC, Xu L. Synthesis and biological evaluation of phosphonate analogues of nevirapine. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1493-7. doi: 10.1016/j.bmcl.2012.12.049., Epub 2012 Dec 21. PMID:23375792 doi:http://dx.doi.org/10.1016/j.bmcl.2012.12.049
