3j4j

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Template:STRUCTURE 3j4j

Contents

Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map

Template:ABSTRACT PUBMED 24029017

Function

[IF2_THET8] One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).

About this Structure

3j4j is a 1 chain structure with sequence from Thermus thermophilus hb8. Full crystallographic information is available from OCA.

Reference

  • Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP. Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15656-61. doi:, 10.1073/pnas.1309578110. Epub 2013 Sep 12. PMID:24029017 doi:10.1073/pnas.1309578110

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OCA

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