4k1g

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Template:STRUCTURE 4k1g

Contents

Structure of E. coli Nfo(Endo IV)-H69A mutant bound to a cleaved DNA duplex containing a alphadA:T basepair

Template:ABSTRACT PUBMED 23898172

Function

[END4_ECOLI] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.

About this Structure

4k1g is a 8 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

See Also

Reference

  • Mazouzi A, Vigouroux A, Aikeshev B, Brooks PJ, Saparbaev MK, Morera S, Ishchenko AA. Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3071-80. doi:, 10.1073/pnas.1305281110. Epub 2013 Jul 29. PMID:23898172 doi:http://dx.doi.org/10.1073/pnas.1305281110

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