3v8s

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Template:STRUCTURE 3v8s

Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18)

Template:ABSTRACT PUBMED 22272748

About this Structure

3v8s is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu J, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Fragment-based and Structure-guided Discovery and Optimization of Rho Kinase Inhibitors. J Med Chem. 2012 Jan 24. PMID:22272748 doi:10.1021/jm201289r

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