4ffb

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Template:STRUCTURE 4ffb

Contents 1 A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase 2 Function 3 About this Structure 4 See Also 5 Reference

A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase

Template:ABSTRACT PUBMED 22904013

Function

[TBA1_YEAST] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [STU2_YEAST] May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. [TBB_YEAST] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

About this Structure

4ffb is a 3 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

See Also

• Tubulin

Reference

• Ayaz P, Ye X, Huddleston P, Brautigam CA, Rice LM. A TOG:alphabeta-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase. Science. 2012 Aug 17;337(6096):857-60. PMID:22904013 doi:10.1126/science.1221698