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4bv0

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Template:STRUCTURE 4bv0

Contents

High Resolution Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion

Template:ABSTRACT PUBMED 24453215

Function

[NTR1_RAT] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. [NEUT_RAT] Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

About this Structure

4bv0 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A. Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli. Proc Natl Acad Sci U S A. 2014 Jan 22. PMID:24453215 doi:http://dx.doi.org/10.1073/pnas.1317903111

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OCA

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