3spd
From Proteopedia
Contents |
Crystal structure of aprataxin ortholog Hnt3 in complex with DNA
Template:ABSTRACT PUBMED 21984208
Function
[APTX_SCHPO] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
About this Structure
3spd is a 8 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA.
Reference
- Gong Y, Zhu D, Ding J, Dou CN, Ren X, Gu L, Jiang T, Wang DC. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 2011 Oct 9;18(11):1297-9. doi: 10.1038/nsmb.2145. PMID:21984208 doi:10.1038/nsmb.2145
