1aq1

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Image:1aq1.gif

1aq1, resolution 2.0Å

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

Overview

Staurosporine exhibits nanomolar IC50 values against a wide range of, protein kinases. The structure of a CDK2 staurosporine complex explains, the tight binding of this inhibitor, and suggests features to be exploited, in the design of specific inhibitors of CDKs.

About this Structure

1AQ1 is a [Single protein] structure of sequence from [Homo sapiens] with STU as [ligand]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: STB. Full crystallographic information is available from [OCA].

Reference

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743

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