Structural highlights
Publication Abstract from PubMed
A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.
Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.,Lee J, Kim KH, Jeong S Bioorg Med Chem Lett. 2011 Jul 15;21(14):4203-5. Epub 2011 May 27. PMID:21684737[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Lee J, Kim KH, Jeong S. Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4203-5. Epub 2011 May 27. PMID:21684737 doi:10.1016/j.bmcl.2011.05.081
