1et4
From Proteopedia
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CRYSTAL STRUCTURE OF A VITAMIN B12 BINDING RNA APTAMER WITH LIGAND AT 2.3 A
Overview
BACKGROUND: The 3.0 A crystal structure of the vitamin B(12) RNA aptamer, revealed an unusual tertiary structure that is rich in novel RNA, structural motifs. Important details of the interactions that stabilize, noncanonical base pairing and the role of solvent in the structure were, not apparent owing to the limited resolution. RESULTS: The structure of, the vitamin B(12) RNA aptamer in complex with its ligand has been, determined at 2.3 A resolution by X-ray crystallography. The, crystallographic asymmetric unit contains five independent copies of the, aptamer-vitamin B(12) complex, making it possible to accurately define, well-conserved features. The core of the aptamer contains an unusual, water-filled channel that is buried between the three strands of an RNA, triplex. Well-ordered ... [(full description)]
About this Structure
1ET4 is a [Protein complex] structure of sequences from [[1]] with CNC as [ligand]. Structure known Active Site: 1. Full crystallographic information is available from [OCA].
Reference
A water channel in the core of the vitamin B(12) RNA aptamer., Sussman D, Wilson C, Structure. 2000 Jul 15;8(7):719-27. PMID:10903943
Page seeded by OCA on Tue Oct 30 15:11:17 2007
Categories: Protein complex | Sussman, D. | Wilson, C. | CNC | B12 binding rna | Cobalamin | Rna | Vitamin b12
