4lry

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Template:STRUCTURE 4lry

Contents

Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex

Template:ABSTRACT PUBMED 24440518

Function

[DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [DHAR_ECOLI] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis.

About this Structure

4lry is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Shi R, McDonald L, Cygler M, Ekiel I. Coiled-Coil Helix Rotation Selects Repressing or Activating State of Transcriptional Regulator DhaR. Structure. 2014 Jan 14. pii: S0969-2126(13)00471-1. doi:, 10.1016/j.str.2013.11.012. PMID:24440518 doi:http://dx.doi.org/10.1016/j.str.2013.11.012

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