4hxx

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Template:STRUCTURE 4hxx

Contents 1 Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1 2 Function 3 About this Structure 4 See Also 5 Reference

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

Template:ABSTRACT PUBMED 23507151

Function

[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.^{[1] [2]}

About this Structure

4hxx is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

• Aminopeptidase

Reference

• Zhang P, Yang X, Zhang F, Gabelli SB, Wang R, Zhang Y, Bhat S, Chen X, Furlani M, Amzel LM, Liu JO, Ma D. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem. 2013 Feb 21. pii: S0968-0896(13)00147-8. doi:, 10.1016/j.bmc.2013.02.023. PMID:23507151 doi:10.1016/j.bmc.2013.02.023

1. ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
2. ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291