2f8y

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Image:2f8y.gif

2f8y, resolution 1.55Å

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Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.

Contents

Overview

Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.

Disease

Known diseases associated with this structure: Aortic valve disease OMIM:[190198], Leukemia, T-cell acute lymphoblastic OMIM:[190198]

About this Structure

2F8Y is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:16530044

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