4mfv

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Template:STRUCTURE 4mfv

Contents 1 Crystal structure of human CTNNBL1(residues 33~563) 2 Function 3 About this Structure 4 Reference

Crystal structure of human CTNNBL1(residues 33~563)

Template:ABSTRACT PUBMED 24598747

Function

[CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.^{[1] [2]}

About this Structure

4mfv is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

• Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ. Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi:, 10.1107/S139900471303318X. Epub 2014 Feb 22. PMID:24598747 doi:http://dx.doi.org/10.1107/S139900471303318X

1. ↑ Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics. 2003 Mar;81(3):292-303. PMID:12659813
2. ↑ Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009. PMID:18722174 doi:10.1016/j.molcel.2008.07.009