4jb8

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Template:STRUCTURE 4jb8

Contents

Caspase-7 in Complex with DARPin C7_16

Template:ABSTRACT PUBMED 23868333

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jb8 is a 3 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA.

Reference

  • Seeger MA, Zbinden R, Flutsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grutter MG. Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci. 2013 Jul 19. doi: 10.1002/pro.2312. PMID:23868333 doi:10.1002/pro.2312

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OCA

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