3f0t

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3f0t

Contents 1 Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

Template:ABSTRACT PUBMED 21623543

Function

[KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

About this Structure

3f0t is a 2 chain structure with sequence from Herpes simplex virus (type 1 / strain 17). Full crystallographic information is available from OCA.

See Also

• Thymidine kinase

Reference

• Martic M, Pernot L, Westermaier Y, Perozzo R, Kraljevic TG, Kristafor S, Raic-Malic S, Scapozza L, Ametamey S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):293-315. PMID:21623543 doi:10.1080/15257770.2011.581258