4psi

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Template:STRUCTURE 4psi

Contents 1 PIH1D1/phospho-Tel2 complex 2 Function 3 About this Structure 4 Reference

PIH1D1/phospho-Tel2 complex

Template:ABSTRACT PUBMED 24656813

Function

[TELO2_HUMAN] Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.^{[1] [2]}

About this Structure

4psi is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

• Horejsi Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ. Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex. Cell Rep. 2014 Apr 10;7(1):19-26. doi: 10.1016/j.celrep.2014.03.013. Epub 2014, Mar 20. PMID:24656813 doi:http://dx.doi.org/10.1016/j.celrep.2014.03.013

1. ↑ Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J Biol Chem. 2003 Jun 13;278(24):21678-84. Epub 2003 Mar 31. PMID:12670948 doi:http://dx.doi.org/10.1074/jbc.M300286200
2. ↑ Hurov KE, Cotta-Ramusino C, Elledge SJ. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev. 2010 Sep 1;24(17):1939-50. doi: 10.1101/gad.1934210. PMID:20810650 doi:http://dx.doi.org/10.1101/gad.1934210