4ksb

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Template:STRUCTURE 4ksb

Contents 1 Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain 2 Function 3 About this Structure 4 Reference

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Template:ABSTRACT PUBMED 23901103

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.^[1]

About this Structure

4ksb is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, Chang G. Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13386-91. doi:, 10.1073/pnas.1309275110. Epub 2013 Jul 30. PMID:23901103 doi:10.1073/pnas.1309275110

1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718