4g2v

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Template:STRUCTURE 4g2v

Contents

Structure complex of LGN binding with FRMPD1

Template:ABSTRACT PUBMED 23318951

Function

[GPSM2_MOUSE] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [FRPD1_HUMAN] Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.[1]

About this Structure

4g2v is a 2 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pan Z, Shang Y, Jia M, Zhang L, Xia C, Zhang M, Wang W, Wen W. Structural and biochemical characterization of the interaction between LGN and Frmpd1. J Mol Biol. 2013 Mar 25;425(6):1039-49. doi: 10.1016/j.jmb.2013.01.003. Epub 2013, Jan 11. PMID:23318951 doi:10.1016/j.jmb.2013.01.003
  1. ↑ An N, Blumer JB, Bernard ML, Lanier SM. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. J Biol Chem. 2008 Sep 5;283(36):24718-28. Epub 2008 Jun 19. PMID:18566450 doi:M803497200

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