2g7c

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Image:2g7c.gif

2g7c, resolution 2.0Å

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Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc

Overview

Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.

About this Structure

2G7C is a Single protein structure of sequence from Clostridium difficile with as ligand. Full crystallographic information is available from OCA.

Reference

Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409

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