3j0a

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Template:STRUCTURE 3j0a

Contents

Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction

Template:ABSTRACT PUBMED 22173220

Disease

[TLR5_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

[TLR5_HUMAN] Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]

About this Structure

3j0a is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Zhou K, Kanai R, Lee P, Wang HW, Modis Y. Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin. J Struct Biol. 2011 Dec 8. PMID:22173220 doi:10.1016/j.jsb.2011.12.002
  1. ↑ Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106

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