This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3j0a
From Proteopedia
Contents |
Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Template:ABSTRACT PUBMED 22173220
Disease
[TLR5_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
Function
[TLR5_HUMAN] Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]
About this Structure
3j0a is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Zhou K, Kanai R, Lee P, Wang HW, Modis Y. Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin. J Struct Biol. 2011 Dec 8. PMID:22173220 doi:10.1016/j.jsb.2011.12.002
- ↑ Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106
