4irp

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Template:STRUCTURE 4irp

Contents

Crystal structure of catalytic domain of human beta1,4-galactosyltransferase-7 in open conformation with manganses and UDP

Template:ABSTRACT PUBMED 24052259

Disease

[B4GT7_HUMAN] Ehlers-Danlos syndrome, progeroid type. The disease is caused by mutations affecting the gene represented in this entry.

Function

[B4GT7_HUMAN] Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.

About this Structure

4irp is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Tsutsui Y, Ramakrishnan B, Qasba PK. Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding. J Biol Chem. 2013 Nov 1;288(44):31963-70. doi: 10.1074/jbc.M113.509984. Epub 2013, Sep 19. PMID:24052259 doi:http://dx.doi.org/10.1074/jbc.M113.509984

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