This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2h03
From Proteopedia
|
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Overview
The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.
About this Structure
2H03 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Full crystallographic information is available from OCA.
Reference
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta., Amarasinghe KK, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE, Howard BW, Pokross ME, Gray JL, Peters KG, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. Epub 2006 Jun 12. PMID:16759857
Page seeded by OCA on Thu Feb 21 17:36:47 2008
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Amarasinghe, K D. | Clark, C M. | Evdokimov, A G. | Gray, J L. | Maier, M B. | Mekel, M. | Nichols, R. | Peters, K G. | Pokross, M E. | Walter, R L. | 3UN | CL | MG | Drug design | Inhibitor | Phosphatase | Protein tyrosine phosphatase | Sulfamic acid | Wpd-loop
