4f3f

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Template:STRUCTURE 4f3f

Contents 1 Crystal Structure of Msln7-64 MORAb-009 FAB complex 2 Disease 3 Function 4 About this Structure 5 Reference

Crystal Structure of Msln7-64 MORAb-009 FAB complex

Template:ABSTRACT PUBMED 22787150

Disease

[MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.

Function

[MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.^{[1] [2]} Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.^{[3] [4]}

About this Structure

4f3f is a 3 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895 and Human. Full crystallographic information is available from OCA.

Reference

• Ma J, Tang WK, Esser L, Pastan I, Xia D. Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. J Biol Chem. 2012 Sep 28;287(40):33123-31. Epub 2012 Jul 11. PMID:22787150 doi:http://dx.doi.org/10.1074/jbc.M112.381756

1. ↑ Yamaguchi N, Hattori K, Oh-eda M, Kojima T, Imai N, Ochi N. A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. J Biol Chem. 1994 Jan 14;269(2):805-8. PMID:8288629
2. ↑ Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Miyajima A. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem. 2004 Mar 5;279(10):9190-8. Epub 2003 Dec 15. PMID:14676194 doi:http://dx.doi.org/10.1074/jbc.M312372200
3. ↑ Yamaguchi N, Hattori K, Oh-eda M, Kojima T, Imai N, Ochi N. A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. J Biol Chem. 1994 Jan 14;269(2):805-8. PMID:8288629
4. ↑ Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Miyajima A. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem. 2004 Mar 5;279(10):9190-8. Epub 2003 Dec 15. PMID:14676194 doi:http://dx.doi.org/10.1074/jbc.M312372200