4jzl

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Template:STRUCTURE 4jzl

Contents

Crystal structure of BAP31 vDED at alkaline pH

Template:ABSTRACT PUBMED 23967155

Disease

[BAP31_HUMAN] BCAP31 is deleted in the chromosome Xq28 deletion syndrome which involves BCAP31 and the and the promoter region of ABCD1.

Function

[BAP31_HUMAN] May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.[1] [2]

About this Structure

4jzl is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Quistgaard EM, Low C, Moberg P, Guettou F, Maddi K, Nordlund P. Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31. PLoS One. 2013;8(8):e71111. doi: 10.1371/journal.pone.0071111. PMID:23967155 doi:10.1371/journal.pone.0071111
  1. ↑ Annaert WG, Becker B, Kistner U, Reth M, Jahn R. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J Cell Biol. 1997 Dec 15;139(6):1397-410. PMID:9396746
  2. ↑ Nguyen M, Breckenridge DG, Ducret A, Shore GC. Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Mol Cell Biol. 2000 Sep;20(18):6731-40. PMID:10958671

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