2hth

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Image:2hth.jpg

2hth, resolution 2.70Å

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Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain

Contents

Overview

The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.

Disease

Known disease associated with this structure: Cleft palate, isolated OMIM:[191339]

About this Structure

2HTH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:17057716

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