Publication Abstract from PubMed
Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.
Apo and inhibitor complex structures of BACE (beta-secretase).,Patel S, Vuillard L, Cleasby A, Murray CW, Yon J J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
