Structural highlights
Disease
[LAMP2_HUMAN] Glycogen storage disease due to LAMP-2 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
Function
[LAMP2_HUMAN] Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.[1]
References
- ↑ Fritz G, Dosch J, Thielmann HW, Kaina B. Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains. J Biol Chem. 1993 Oct 5;268(28):21102-12. PMID:8407947
