2ptk
From Proteopedia
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CHICKEN SRC TYROSINE KINASE
Overview
The Src protein tyrosine kinase plays a critical role in a variety of, signal transduction pathways. Strict regulation of its activity is, necessary for proper signalling. We present here the crystal structure of, chicken Src which is phosphorylated at Tyr527 and represents its least, active form. Our structure, similar to the recently reported human Hck and, Src structures, contains the SH3, SH2 and the kinase domains and the, C-terminal regulatory tail but not the N-terminal unique domain. The SH3, domain uses its hydrophobic surface to coordinate the SH2-kinase linker, such that residues Gln251 and Leu255 specifically interact with side, chains in the beta2-beta3 and the alphaC-beta4 loops of the N-terminal, lobe opposite of the kinase active site. This position of the SH3 domain, and ... [(full description)]
About this Structure
2PTK is a [Single protein] structure of sequence from [Gallus gallus]. Active as [Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [2.7.1.112]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [OCA].
Reference
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions., Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G, Wierenga RK, J Mol Biol. 1997 Dec 19;274(5):757-75. PMID:9405157
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