3ugx

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Template:STRUCTURE 3ugx

Contents

Crystal Structure of Visual Arrestin

Template:ABSTRACT PUBMED 22306737

Disease

[ARRS_BOVIN] Note=S-antigen induces autoimmune uveitis.

Function

[ARRS_BOVIN] Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.

About this Structure

3ugx is a 4 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Granzin J, Cousin A, Weirauch M, Schlesinger R, Buldt G, Batra-Safferling R. Crystal Structure of p44, a Constitutively Active Splice Variant of Visual Arrestin. J Mol Biol. 2012 Mar 9;416(5):611-8. Epub 2012 Jan 27. PMID:22306737 doi:10.1016/j.jmb.2012.01.028

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